anti-hyperglycaemic and antioxidant effects of bidens tripartita and quantitative analysis on its active principles

نویسندگان

nilüfer orhan department of pharmacognosy, faculty of pharmacy, gazi university, 06330, etiler, ankara, turkey

ülkü gökçen i̇çöz republic of turkey social security institution, 06520, balgat, ankara, turkey

levent altun department of pharmacognosy, faculty of pharmacy, ankara university, 06500, tandogan, ankara, turkey

mustafa aslan department of pharmacognosy, faculty of pharmacy, gazi university, 06330, etiler, ankara, turkey

چکیده

objective(s): bidens species are used for their antidiabetic properties traditionally in many countries. aim of this study is to evaluate hypoglycaemic and antidiabetic activity of bidens tripartita extract and to identify its active compounds through bioactivity guided isolation technique. materials and methods: hypoglycaemic effects of b. tripartita extract and its sub-extracts were investigated in normal and glucose-hyperglycaemic rats. streptozotocin induced diabetic rats were used to examine antidiabetic activity of the extract and its sub-extracts after acute and sub-acute administration. additionally, in vitro enzyme inhibitory and antioxidant activities were evaluated. hplc analyses were carried out to determine the active constituents of the extract and its sub-extracts. results: through in vivo bioactivity-guided fractionation process, ethyl acetate and n-buthanol                  sub-extracts were found to have potent antidiabetic activity. in vitro enzyme inhibitory activities of the same sub-extracts were found to be potent. the highest total phenol, flavonoid contents and radical scavenging activity was determined in ethyl acetate sub-extract. according to lc-ms analyses, chlorogenic acid, luteolin and 7-o-glucoside of luteolin (cynaroside) were determined as the main components of the active sub-extracts. conclusion: according to our results, b. tripartita has potent antidiabetic activity and its active constituents might be beneficial for diabetes and its complications.

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منابع مشابه

Anti-hyperglycaemic and antioxidant effects of Bidens tripartita and quantitative analysis on its active principles

Objective(s): Bidens species are used for their antidiabetic properties traditionally in many countries. Aim of this study is to evaluate hypoglycaemic and antidiabetic activity of Bidens tripartita extract and to identify its active compounds through bioactivity guided isolation technique. Materials and Methods: Hypoglycaemic effects of B. tripartita extract and its sub-extracts were investig...

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Anti-hyperglycaemic and antioxidant effects of Bidens tripartita and quantitative analysis on its active principles

OBJECTIVES Bidens species are used for their antidiabetic properties traditionally in many countries. Aim of this study is to evaluate hypoglycaemic and antidiabetic activity of Bidens tripartita extract and to identify its active compounds through bioactivity guided isolation technique. MATERIALS AND METHODS Hypoglycaemic effects of B. tripartita extract and its sub-extracts were investigate...

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Extracts from herb and flowers of Bidens tripartita L. (Asteraceae), obtained using solvents of different polarity, were studied for their radical scavenging effects. Antioxidant activities of pure flavonoids: flavanomarein (isookanin 7-O-glucoside), cynaroside (luteolin 7-O-glucoside) and luteolin, which had been isolated from this plant, were also evaluated. Radical-scavenging activity was me...

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عنوان ژورنال:
iranian journal of basic medical sciences

جلد ۱۹، شماره ۱۰، صفحات ۱۱۱۴-۱۱۲۴

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